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The 7.3-magnitude earthquake struck at a depth of 11.5 miles, according to the United States Geological Survey.
It was followed closely by at least five aftershocks measuring from magnitude 5.6 to magnitude 6.3.
The epicenter of the earthquake is located near the town of Namche Bazaar, close to Mount Everest and about 47 miles east of the capital of Kathmandu.
In Kathmandu, today's quake sent people rushing outside of their homes into the streets. Police gave no immediate estimate on damage.
“Felt like walking on deck of boat as we made way to safety,” Rose Foley, a UNICEF official based in Kathmandu, wrote following the earthquakes.
The earthquake activity followed an April 25 earthquake in Nepal that killed more than 8,000 people.
Indian Embassy spokesman Abhay Kumar said some buildings in Kathmandu collapsed, but he gave no further details about how many or where they were.
Experts say the April 25 quake caused extensive structural damage even in buildings that did not topple, and that many could be in danger of future collapse.
The Associated Press contributed to this report.