ABC News' Eloise Harper Reports: Hillary Clinton vs. Bill O'Reilly - it's finally going to happen.First reported exclusively by the Drudge Report, Sen. Hillary Clinton, D-N.Y., will appear in a pre-taped interview on Wednesday's edition of "The O'Reilly Factor" on FOX News. Neither Clinton nor Sen. Barack Obama, D-Ill., have appeared on the conservative talk show host's popular program although an Obama staffer famously tangled with O'Reilly at a New Hampshire event in January.Marvin Nicholson, a veteran of Sen. John Kerry's, D-Mass., 2004 presidential campaign, put his 6' 8" frame between O'Reilly, his cameraman, and Obama.Upset with Nicholson, O'Reilly maneuvered around a steel gate barricade, yelled expletives, and called Obama's national trip director "low class."Secret Service quickly stepped in and told O'Reilly to get back. After the commotion, Obama shook hands with O'Reilly but has yet to go as far as Clinton, agreeing to appear one-on-one with the often combative host.O'Reilly did attend a Clinton rally on the same day as the aforementioned Obama incident. The Democratic crowd booed but Clinton complimented him on his willingness to show up at the event.The much anticipated interview will take place via satellite with Clinton in South Bend, Indiana, on Wednesday.ABC News' Sunlen Miller contributed to this report.