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Ned Potter is the science correspondent for ABC's "World News with Charles Gibson." He has reported on such topics as space exploration, the human genome and climate change.

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Artificial DNA

January 24, 2008 3:03 PM

Craigventer_080124_main J. Craig Venter, the iconoclast scientist who led part of the giant project to read the human genome, has not stopped there.  Since the mid-1990s he's been on a quest to create nothing less than artificial life.

That's right, synthetic life--and today Venter and his team announce a major advance.  They report, in the journal Science, that they have synthesized the genome -- the complete DNA -- of a bacterium called Mycoplasma genitalium

"We consider this the second in significant steps of a three-step process in our attempts to make the first synthetic organism," Venter said this morning in a telephone briefing from Davos, Switzerland, where he's attending the World Economic Forum.

They picked the bacterium because it's relatively simple; while the DNA in human cells has three billion "base pairs" -- rungs, if you will, on that familiar spiral ladder you so often see -- M. genitalium has fewer than 600,000. 

Venter talks of creating synthetic organisms that create energy to take the place of fossil fuels, or thrive by consuming toxic chemicals to allow easier cleanup.  Perhaps, he says, some can be created that consume large amounts of carbon dioxide, helping to stave off climate change. 

But, obviously, if he succeeds, Venter will raise all sorts of moral and ethical questions.  He knows that, and, when he began, assembled a panel of bioethicists and others to consider the implications.

I spoke to Glenn McGee, who edits the American Journal of Bioethics, and was on the panel, and he urges caution.  Will this project face the same political backlash as cloning?  What if a bunch of people "with a bit of knowhow and a lot of anger" decided to create, say, synthetic anthrax?

Finally, he asks, isn't this playing God, with all that implies?  Heavy stuff.

January 24, 2008 | Permalink | Share | User Comments (22)

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My main concern is that they may create something useful, but it gets loose and mutates into something else, a la "The Andromeda Strain." That scares the hell out of me. Since I'm a devout atheist, the god-playing aspect doesn't worry me in the least. But the human frailty aspect does worry me. Even absent the terrorism ideas, the fact remains that some one involved in this project may utter the most fearsome word in the language: Oops.

Posted by: Andy | Jan 24, 2008 3:26:30 PM

Can't anyone see what a major breakthrough this is and how this new discovery could be applied. Yes there is risk when creating engineered lifeforms. However it doesn't mean we could not use this new artificial DNA to enhance the Human genome itself. We could make humans immune to all disease and thus make biological threats a non-issue.

Posted by: Connor | Jan 24, 2008 3:50:27 PM

"A little knowledge is a dangerous thing." I agree completely with Andy in that scientists know enough about the subject to get themselves in trouble in their creation of synthetic organisms, but not enough to get themselves out of trouble if something went terribly wrong. I look forward to the bioethics panel's recommendations, if, for no other reason, to see how they view the creation of synthetic life and all of its implications.

Posted by: chuck | Jan 24, 2008 4:00:03 PM

Tongue firmly in cheek!
..but can we make it so that it evolves?

Posted by: Andy Clark | Jan 24, 2008 4:14:01 PM

Make humans immune to disease to thwart biological threats? Sounds like the same cat and mouse game we already have with computers. Hmm, monthly immune system virus patches, I'm seeing a money machine.
I'd rather just do with less humans.

Posted by: dougcp | Jan 24, 2008 4:23:32 PM

LOL. I agree with dougcp. That is, of course, the answer to most of our problems. The more of us there are, the more mischief we have to commit to support us. We've already got 6.6 billion egos pulling at us. We don't need more.

Posted by: Andy | Jan 24, 2008 4:30:00 PM

Andy Clark: I doubt you could make it so that it doesn't evolve.

Posted by: Bgascan | Jan 24, 2008 4:50:21 PM

That's all we need is a rogue man-made bacteria. ...and at this guy's suggestion, there is likely somebody working on a "synthetic" version of anthrax right now. How can someone work so hard at being so backwards in their thinking?

Posted by: Daleri | Jan 24, 2008 5:50:13 PM

My biggest concern is not knowing all the potential risks; then one day, a diligent scientist discovers that it was this experiment that lead to the near extinction of Mankind by sterilizing men or women. We still dont know all we need to know about viruses and bacterium; too many variations of exo-conditions affect their reproduction and lifecycles. They change regularly on their own mutating/evolving to survive. I hardly think giving them a push is a good idea. Its almost like kids and their chemistry sets: "Lets do it and see what happens."

Posted by: Mycusine | Jan 24, 2008 6:14:47 PM

We need to address problems as they arise, not look for problems to create. So many things that could happen, don't happen when we don't worry about them happening. We cause so many needless problems that we create ourselves.

The Bible speaks of various "plagues" that will come in the end times. Most of our problems are self inflicted.

My suggestion is to work with the set of problems and issues that we already have. We hardly have enough time for these issues that we now face. We don't need more problems than we can handle.

Posted by: Daleri | Jan 24, 2008 6:16:34 PM

I agree, this can have potentially deadly reprocussions. I would advise caution. Like the bicycle warnings say: You can lose control, fall, and die. I hope we don't lose control, fall, and die doing this. God only knows all the other stuff that kills us, including bicycles.

Posted by: Lawrence | Jan 24, 2008 6:18:02 PM

Our "knowledge" has become our curse.

Everyone should know that our economy is so bad because of the uncertainty of what could happen because of our "knowledge" getting into the wrong hands. Our "knowledge" was supposed to save us and look what it has done to us!

...and does anyone have time for the knowledge of the Lord? Could it be that we are "knowing" all of the wrong things? ...that our knowledge is of evil rather than of good? ...that we are in the flesh rather than in the Spirit? ...that we know of the temporal and not the eternal?

Posted by: Daleri | Jan 24, 2008 6:43:23 PM

If we don't keep at least up-to-date with knowledge about this subject, we will be left completely defenseless when someone with willingness to experiment but no inconvenient ethical scruples (the North Koreans? China? Iran?) launches a custom virus against us.

We need this research for ourselves, conducted in the light of day and with appropriate public safeguards, to ensure that we have enough knowledge about the subject to deal with the possibility that someone else, developing the technology in secret, chooses to use it as a weapon against us.

And yes, to the earlier poster, this is very much like the situation with computers. Specifically, it makes no sense to ban computer security research on the grounds that it might encourage hackers. Hackers don't need encouragement -- they are capable of developing their skills on their own, in secret. Security research is what protects the rest of us from them.

Posted by: Spork | Jan 24, 2008 9:37:48 PM

People keeping asking why we should invest in space travel, lunar bases, space stations, etc... The point is so we don't kill ourselves off with a bio "oops". Bio development and testing should be moved outside earth's atmosphere. Let scientists go crazy "playing god" in their own isolated world. Too much risk of a containment breach here on earth.
I really look forward to what the research produces. Just want proper precautions.

Posted by: Shaun | Jan 24, 2008 10:12:24 PM

It is futile to be looking for problems that may never materialize. There are so many things that could happen that never do happen. We need to focus on the problems that we now have. In other words, it does no good to worry about things that we have no control over.

We need to learn as much as we can about DNA so that if the need arises, we can address only those needs that we have. The problem is if we cause more harm than we do good.

Posted by: Daleri | Jan 24, 2008 10:31:26 PM

Ethics and politics may delay science until a suitable justification for the advancement is found (financial, protective/destructive, betterment of society or simple curiousity), but it will not stop it.

Posted by: bamf | Jan 24, 2008 11:34:29 PM

What will happen next? Artificial politicians? Oops! Too late. We already have them.

Posted by: rakko | Jan 25, 2008 2:35:46 AM

Andy Clark
The question you need to ask is "do we want it to evolve and if so, how do we maintain control?"

Posted by: Ed | Jan 25, 2008 6:01:52 PM

Ed

If this turns out to be life then it must be capable of reproducing itself. As soon as that happens there is the possibility of mutation in its genes just as there is in the genes of anything else living on this planet.

So, Bgascan is probably right and we won't be able to stop it from evolving.

If we somehow stop it from reproducing then is it still "alive" or will it be like a virus or virus particle?

Posted by: Andy Clark | Jan 25, 2008 7:40:21 PM

From this and the other articles on this press release I gathered that the material in question is a synthetic bacterium based on Mycoplasma genitalium. It isn't clear as to whether they actually made it or just figured out how to. But using the same code the synthetic will have the same properties as the original and be subject to the same mutations. The key here will be in control of the mutations as they have done in fruit flies. As for the danger, it is the same as it is for the original but with control can be less than for the original. This combined with new nanotechnology should be interesting.

Posted by: Ed | Jan 26, 2008 12:55:56 AM

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